(19)

(11)

EP 0 386 109 A1

(12)

(43) Date of publication: 12.09.1990 Bulletin 1990/37 (21) Application number: 88910226.0 (22) Date of filing: 10.11.1988

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61K 31/ 557( . ) A61K 31/ 66( . ) A61K 38/ 19( . ) A61K 38/ 29( . ) A61P 19/ 10( . ) A61K 31/ 195( . ) A61K 31/ 56( . ) A61K 33/ 16( . ) A61K 38/ 23( . ) A61P 3/ 00( . ) A61P 43/ 00( . ) (86) International application number: PCT/US1988/003922 (87) International publication number: WO 1989/004173 (18.05.1989 Gazette 1989/11)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 12.11.1987 US 19870119611 (71) Applicant: SCHERING CORPORATION Kenilworth New Jersey 07033 (US)	(72) Inventor: BLACK, Hugh, E. Sparta, NJ 07871 (US) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)