(19)

(11)

EP 0 390 785 A1

(12)

(43) Date of publication: 10.10.1990 Bulletin 1990/41 (21) Application number: 88908730.0 (22) Date of filing: 07.10.1988

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C07K 14/ 36( . ) (86) International application number: PCT/GB1988/000831 (87) International publication number: WO 1989/003422 (20.04.1989 Gazette 1989/09)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 08.10.1987 GB 19870023661 (71) Applicant: BRITISH BIO-TECHNOLOGY LIMITED Cowley Oxford, OX4 5LY (GB)	(72) Inventor: EDWARDS, Richard, Mark Thame Oxon (GB) (74) Representative: Sheard, Andrew Gregory, et al  Kilburn & Strode 30, John Street London WC1N 2DD London WC1N 2DD (GB)