(19)

(11)

EP 0 391 898 A1

(12)

(43) Date of publication: 17.10.1990 Bulletin 1990/42 (21) Application number: 88905837.0 (22) Date of filing: 21.07.1988

(51) International Patent Classification (IPC):  A61K 31/ 575( . ) A61P 31/ 12( . ) C07J 9/ 00( . ) A61K 31/ 56( . ) A61P 31/ 18( . ) (86) International application number: PCT/EP1988/000660 (87) International publication number: WO 1989/000424 (26.01.1989 Gazette 1989/03)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 22.07.1987 EP 19870110621 07.01.1988 EP 19880100128 (71) Applicant: LEO PHARMACEUTICAL PRODUCTS B.V. NL-1382 JS Weesp (NL)	(72) Inventors: FABER, Johan, Viggo DK-1360 Copenhagen K (DK) GODTFREDSEN, Wagn, Ole DK-3500 Vaerloese (DK) (74) Representative: Kjerrumgaard, Bent  c/o Th. Ostenfeld Patentbureau A/S Bredgade 41 P.O. Box 1183 DK-1011 Copenhagen K DK-1011 Copenhagen K (DK)