(19)

(11)

EP 0 391 957 A1

(12)

(43) Date of publication: 17.10.1990 Bulletin 1990/42 (21) Application number: 89900676.0 (22) Date of filing: 21.12.1988

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61P 1/ 00( . ) A61P 9/ 00( . ) A61P 11/ 08( . ) A61P 15/ 00( . ) A61P 25/ 24( . ) A61P 35/ 00( . ) C07K 1/ 20( . ) C07K 14/ 575( . ) C12N 15/ 16( . ) C12R 1/ 19( . ) A61K 38/ 00( . ) A61P 1/ 02( . ) A61P 9/ 08( . ) A61P 13/ 02( . ) A61P 25/ 18( . ) A61P 25/ 26( . ) C07H 21/ 04( . ) C07K 14/ 00( . ) C07K 19/ 00( . ) C12P 21/ 02( . ) (86) International application number: PCT/SE1988/000696 (87) International publication number: WO 1989/005857 (29.06.1989 Gazette 1989/14)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 23.12.1987 SE 19870005139 (71) Applicant: TRION FORSKNING- OCH UTVECKLINGS AKTIEBOLAG S-191 41 Sollentuna (SE)	(72) Inventors: BARTFAI, Tamas S-182 74 Stocksund (SE) TJÖRNHAMMAR, Marie-Louise S-117 24 Stockholm (SE) SIMONCSITS, András S-117 24 Stockholm (SE) KALMAN, Mikl(RTM)s H-6726 Szeged (HU) CSERPAN, Imre H-6723 Szeged (HU) (74) Representative: Wiklund, Erik  AWAPATENT AB, Box 5117 S-200 71 Malmö S-200 71 Malmö (SE)