(19)

(11)

EP 0 391 999 A1

(12)

(43) Date of publication: 17.10.1990 Bulletin 1990/42 (21) Application number: 89911204.0 (22) Date of filing: 22.09.1989

(51) International Patent Classification (IPC):  A61K 38/ 55( . ) C12N 9/ 64( . ) C07K 14/ 81( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1989/004140 (87) International publication number: WO 1990/003390 (05.04.1990 Gazette 1990/08)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 23.09.1988 US 19880248817 20.09.1989 US 19890408595 (71) Applicant: CORVAS, INC. La Jolla, CA 92037 (US)	(72) Inventor: PEPE, Michael, G. San Diego, CA 92109 (US) (74) Representative: Fisher, Adrian John  CARPMAELS & RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)