(19)

(11)

EP 0 393 153 A1

(12)

(43) Date of publication: 24.10.1990 Bulletin 1990/43 (21) Application number: 89903609.0 (22) Date of filing: 28.02.1989

(51) International Patent Classification (IPC):  C12N 5/ 06( . ) C12N 5/ 02( . ) A61K 35/ 52( . ) (86) International application number: PCT/US1989/000800 (87) International publication number: WO 1989/008142 (08.09.1989 Gazette 1989/21)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 29.02.1988 US 19880162160 (71) Applicant: RUSH-PRESBYTERIAN-ST.LUKE'S MEDICAL CENTER Chicago, IL 60612 (US)	(72) Inventors: RAWLINS, Richard, Graham Oak Park, IL 60302 (US) DMOWSKI, Wojiech, Paul Oak Park, IL 60302 (US) (74) Representative: Bizley, Richard Edward, et al  BOULT, WADE & TENNANT 27 Furnival Street London EC4A 1PQ London EC4A 1PQ (GB)