(19)

(11)

EP 0 394 261 A1

(12)

(43) Date of publication: 31.10.1990 Bulletin 1990/44 (21) Application number: 88906509.0 (22) Date of filing: 06.07.1988

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61P 7/ 02( . ) C07K 14/ 00( . ) C12N 9/ 64( . ) G01N 33/ 543( . ) A61K 38/ 46( . ) C07H 21/ 04( . ) C12N 9/ 48( . ) C12N 9/ 72( . ) (86) International application number: PCT/US1988/002263 (87) International publication number: WO 1989/000191 (12.01.1989 Gazette 1989/02)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 06.07.1987 US 19870070012 20.04.1988 US 19880184121 (71) Applicant: GENETICS INSTITUTE, INC. Cambridge, MA 02140 (US)	(72) Inventors: LARSEN, Glenn, R. Sudburry, MA 01776 (US) AHERN, Tim Arlington, MA 02174 (US) LANGER-SAFER, Pennina Brookline, MA 02146 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 D-81634 München D-81634 München (DE)