(19)
(11) EP 0 394 893 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
15.05.1991 Bulletin 1991/20

(43) Date of publication A2:
31.10.1990 Bulletin 1990/44

(21) Application number: 90107615.8

(22) Date of filing: 23.04.1990
(51) International Patent Classification (IPC)5: C07D 473/18, C07D 473/30, C07D 473/40, C07D 473/32, C07D 473/16, C07D 405/04, C07D 307/20, A61K 31/52, A61K 31/505
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU NL SE

(30) Priority: 24.04.1989 US 342048

(71) Applicant: E.R. SQUIBB & SONS, INC.
Princeton New Jersey 08543-4000 (US)

(72) Inventors:
  • Zahler, Robert
    Princeton, NJ (US)
  • Tino, Joseph Anthony
    Robbinsville, NJ (US)

(74) Representative: VOSSIUS & PARTNER 
Postfach 86 07 67
81634 München
81634 München (DE)


(56) References cited: : 
   
       


    (54) Purinyl and pyrimidinyl tetrahydrofurans


    (57) Antiviral activity is exhibited by compounds having the formula

    and pharmaceutically acceptable salts thereof wherein R1 is a purine or pyrimidine base or an analog thereof and R2 and R3 are independently hydrogen, -PO3H2 or - -X7, wherein X7 is hydrogen, alkyl, substituted alkyl or aryl.






    Search report