(19)

(11)

EP 0 396 653 A1

(12)

(43) Date of publication: 14.11.1990 Bulletin 1990/46 (21) Application number: 89909550.0 (22) Date of filing: 29.08.1989

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 39/ 395( . ) A61P 5/ 00( . ) C07K 14/ 00( . ) C07K 14/ 10( . ) C07K 14/ 575( . ) C07K 14/ 705( . ) C12N 15/ 62( . ) C12R 1/ 91( . ) A61K 39/ 29( . ) A61K 39/ 42( . ) C07K 7/ 23( . ) C07K 14/ 02( . ) C07K 14/ 18( . ) C07K 14/ 59( . ) C07K 19/ 00( . ) C12P 21/ 00( . ) (86) International application number: PCT/EP1989/001013 (87) International publication number: WO 1990/002187 (08.03.1990 Gazette 1990/06)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 30.08.1988 US 19880246558 (71) Applicant: Applied Research Systems ARS Holding N.V. Curaçao (AN)	(72) Inventors: CHAPPEL, Scott, C. Boston, MA 02114 (US) NUGENT, Noreen, P. Framingham, MA 01701 (US) (74) Representative: Ritter, Stephen David  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)