(19)

(11)

EP 0 397 659 A1

(12)

(43) Date of publication: 22.11.1990 Bulletin 1990/47 (21) Application number: 88909867.0 (22) Date of filing: 07.10.1988

(51) International Patent Classification (IPC):  C12M 1/ 00( . ) C12Q 1/ 68( . ) G01N 33/ 553( . ) C12Q 1/ 04( . ) G01N 33/ 543( . ) G01N 33/ 68( . ) (86) International application number: PCT/US1988/003529 (87) International publication number: WO 1989/003533 (20.04.1989 Gazette 1989/09)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 09.10.1987 US 19870107251 (71) Applicant: NYGENE CORPORATION Yonkers, NY 10701 (US)	(72) Inventors: PIETRONIGRO, Dennis, D. Yorktown Heights, NY 10598 (US) STERNICK, John, L. Hackensack, NJ 07601 (US) RUEMER, Robert, J. Pleasantville, NY 10570 (US) MATTES-POUND, Mary, Lou Brewster, NY 10509 (US) (74) Representative: Warren, Keith Stanley, et al  BARON & WARREN 18 South End Kensington London W8 5BU London W8 5BU (GB)