(19)

(11)

EP 0 397 751 A1

(12)

(43) Date of publication: 22.11.1990 Bulletin 1990/47 (21) Application number: 89901958.0 (22) Date of filing: 27.01.1989

(51) International Patent Classification (IPC):  A61K 38/ 04( . ) C07K 14/ 60( . ) C07K 14/ 575( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1989/000245 (87) International publication number: WO 1989/007113 (10.08.1989 Gazette 1989/18)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 29.01.1988 US 19880150301 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, Michigan 49001 (US)	(72) Inventor: FRIEDMAN, Alan, R. Portage, MI 49081 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)