(19)

(11)

EP 0 398 962 A1

(12)

(43) Date of publication: 28.11.1990 Bulletin 1990/48 (21) Application number: 89902196.0 (22) Date of filing: 03.02.1989

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 5/ 10( . ) C12N 9/ 72( . ) C12N 1/ 21( . ) C12N 9/ 64( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1989/000465 (87) International publication number: WO 1989/007146 (10.08.1989 Gazette 1989/18)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 05.02.1988 US 19880152692 (71) Applicant: INTEGRATED GENETICS, INC. Framingham, MA 01701 (US)	(72) Inventors: MARKLAND, William Milford, MA 01757 (US) LIVINGSTON, David, J. Auburndale, MA 02144 (US) (74) Representative: Sheard, Andrew Gregory, et al  Kilburn & Strode 30, John Street London WC1N 2DD London WC1N 2DD (GB)