(19)

(11)

EP 0 398 983 A1

(12)

(43) Date of publication: 28.11.1990 Bulletin 1990/48 (21) Application number: 89902611.0 (22) Date of filing: 23.12.1988

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C07K 14/ 61( . ) C12N 15/ 70( . ) C12R 1/ 19( . ) C07K 14/ 545( . ) C12N 1/ 21( . ) C12P 21/ 00( . ) (86) International application number: PCT/US1988/004570 (87) International publication number: WO 1989/007141 (10.08.1989 Gazette 1989/18)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 27.01.1988 US 19880149129 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, MI 49001 (US)	(72) Inventors: OLSON, Eric, R. Kalamazoo, MI 49009 (US) WATSON, Edward, B., III Kalamazoo, MI 49009 (US) (74) Representative: Perry, Robert Edward, et al  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)