(19)
(11) EP 0 400 010 A1

(12)

(43) Date of publication:
05.12.1990 Bulletin 1990/49

(21) Application number: 88909683.0

(22) Date of filing: 05.10.1988
(51) International Patent Classification (IPC): 
C12N 15/ 09( . )
A61F 6/ 04( . )
A61K 38/ 00( . )
C07K 1/ 22( . )
C07K 14/ 435( . )
C07K 14/ 73( . )
C12R 1/ 91( . )
 A61F 5/ 44( . )
A61K 35/ 14( . )
A61P 31/ 12( . )
C07K 14/ 00( . )
C07K 14/ 705( . )
C12P 21/ 00( . )
(86) International application number:
PCT/US1988/003454
(87) International publication number:
WO 1989/003222 (20.04.1989 Gazette 1989/09)
(84) Designated Contracting States:
AT BE CH DE FR GB IT LI LU NL SE

(30) Priority: 08.10.1987 US 19870106185
14.01.1988 US 19880144313
14.06.1988 US 19880206585
11.07.1988 US 19880217475

(71) Applicant: DANA-FARBER CANCER INSTITUTE
Boston, MA 02115 (US)

(72) Inventors:
  • REINHERZ, Ellis
    Lincoln, MA 01773 (US)
  • HUSSEY, Rebecca
    Lincoln, MA 01773 (US)
  • SODROSKI, Joseph
    Medford, MA 02155 (US)
  • RICHARDSON, Neil
    (deceased) (US)
  • CLAYTON, Linda, K.
    Jamacia Plain, MA 02130 (US)

(74) Representative: Holdcroft, James Gerald, Dr., et al 
Graham Watt & Co., Riverhead
Sevenoaks, Kent TN13 2BN
Sevenoaks, Kent TN13 2BN (GB)

   


(54) SOLUBLE HUMAN CD4 FRAGMENTS AND USES THEREFOR