(19)
(11) EP 0 400 054 A1

(12)

(43) Date of publication:
05.12.1990 Bulletin 1990/49

(21) Application number: 89902589.0

(22) Date of filing: 03.02.1989
(51) International Patent Classification (IPC): 
C12N 15/ 09( . )
C12N 5/ 10( . )
C12N 9/ 72( . )
C07K 14/ 00( . )
C12N 9/ 64( . )
(86) International application number:
PCT/US1989/000464
(87) International publication number:
WO 1989/007145 (10.08.1989 Gazette 1989/18)
(84) Designated Contracting States:
AT BE CH DE FR GB IT LI LU NL SE

(30) Priority: 05.02.1988 US 19880152691

(71) Applicant: INTEGRATED GENETICS, INC.
Framingham, MA 01701 (US)

(72) Inventors:
  • LIVINGSTON, David, J.
    Auburndale, MA 02144 (US)
  • MARKLAND, William
    Milford, MA 01757 (US)

(74) Representative: Sheard, Andrew Gregory, et al 
Kilburn & Strode 30, John Street
London WC1N 2DD
London WC1N 2DD (GB)

   


(54) MODIFIED GENE SEQUENCES ENCODING MODIFIED TPA AND PRODUCTS THEREFROM