(19)

(11)

EP 0 400 075 A1

(12)

(43) Date of publication: 05.12.1990 Bulletin 1990/49 (21) Application number: 89903351.0 (22) Date of filing: 06.02.1989

(51) International Patent Classification (IPC):  C12N 9/ 64( . ) A61K 38/ 43( . ) A61P 7/ 02( . ) C12N 9/ 72( . ) C12P 21/ 00( . ) A61K 38/ 00( . ) A61K 38/ 46( . ) C12N 9/ 48( . ) C12N 9/ 82( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1989/000458 (87) International publication number: WO 1989/007641 (24.08.1989 Gazette 1989/20)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 10.02.1988 US 19880154195 (71) Applicant: GENZYME CORPORATION Boston Massachusetts 02111 (US)	(72) Inventors: RASMUSSEN, James, R. Boston, MA 02108 (US) BERGH, Michel Belmont, MA 02178 (US) HIRANI, Shirish Boston, MA 02114 (US) (74) Representative: Deans, Michael John Percy, et al  Lloyd Wise, Tregear & CO. Norman House 105-109 Strand London WC2R OAE London WC2R OAE (GB)