(19)

(11)

EP 0 403 535 A1

(12)

(43) Date of publication: 27.12.1990 Bulletin 1990/52 (21) Application number: 89903438.0 (22) Date of filing: 08.02.1989

(51) International Patent Classification (IPC):  C07D 311/ 12( . ) A61P 31/ 12( . ) C07D 311/ 16( . ) A61K 31/ 37( . ) A61P 43/ 00( . ) C07D 311/ 18( . ) (86) International application number: PCT/US1989/000450 (87) International publication number: WO 1989/007939 (08.09.1989 Gazette 1989/21)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 01.03.1988 US 19880162553 04.05.1988 US 19880190038 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, MI 49001 (US)	(72) Inventors: REUSSER, Fritz Portage, MI 49081 (US) TARPLEY, William, G. Kalamazoo, MI 49008 (US) DOLAK, Lester Plainwell, MI 49080 (US) ALTHAUS, Irene, W. Portage, MI 49002 (US) (74) Representative: Perry, Robert Edward, et al  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)