(19)

(11)

EP 0 403 600 A1

(12)

(43) Date of publication: 27.12.1990 Bulletin 1990/52 (21) Application number: 89910271.0 (22) Date of filing: 16.08.1989

(51) International Patent Classification (IPC):  C07K 1/ 04( . ) C07K 1/ 113( . ) C07K 7/ 06( . ) C07K 1/ 06( . ) C07K 1/ 12( . ) C07K 7/ 08( . ) (86) International application number: PCT/US1989/003509 (87) International publication number: WO 1990/002138 (08.03.1990 Gazette 1990/06)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 18.08.1988 US 19880233677 (71) Applicant: THE ROCKEFELLER UNIVERSITY New York, NY 10021 (US)	(72) Inventor: KONSTANTINOS, Petrakis New York, NY 10021 (US) (74) Representative: Weinhold, Peter, Dr., et al  Patentanwälte Dr. Weinhold, Dannenberg, Dr. Gudel, Schubert Siegfriedstrasse 8 D-80803 München D-80803 München (DE)