(19)

(11)

EP 0 403 605 A1

(12)

(43) Date of publication: 27.12.1990 Bulletin 1990/52 (21) Application number: 89910781.0 (22) Date of filing: 08.09.1989

(51) International Patent Classification (IPC):  C12N 9/ 99( . ) A61K 47/ 48( . ) C07K 1/ 113( . ) C07K 14/ 81( . ) C08G 69/ 10( . ) A61K 38/ 55( . ) A61P 11/ 00( . ) C07K 5/ 06( . ) C07K 17/ 08( . ) C08G 69/ 48( . ) (86) International application number: PCT/US1989/003908 (87) International publication number: WO 1990/002558 (22.03.1990 Gazette 1990/07)

(84) Designated Contracting States: AT BE CH DE ES FR GB GR IT LI LU NL SE (30) Priority: 09.09.1988 US 19880242294 (71) Applicants: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION Lexington, Kentucky 40506-0032 (US) CZECHOSLOVAK ACADEMY OF SCIENCES 111 42 Praha Stare Mesto (CZ)	(72) Inventors: DIGENIS, George, A. Lexington, KY 40502 (US) BANKS, William, R. Louisville, KY 40222 (US) RYPACEK, Frantisek Heyrovsky Square 2 162 06 Prague 6 (CS) AGHA, Bushra Nanuet, NY 10954 (US) (74) Representative: Overbury, Richard Douglas, et al  Haseltine Lake & Co Hazlitt House 28, Southampton Buildings Chancery Lane London WC2A 1AT London WC2A 1AT (GB)