(19)

(11)

EP 0 404 835 A1

(12)

(43) Date of publication: 02.01.1991 Bulletin 1991/01 (21) Application number: 89904461.0 (22) Date of filing: 08.03.1989

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 15/ 863( . ) C12N 7/ 00( . ) (86) International application number: PCT/US1989/000931 (87) International publication number: WO 1989/008716 (21.09.1989 Gazette 1989/23)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 18.03.1988 US 19880169949 (71) Applicant: THE UNITED STATES OF AMERICA, represented by THE SECRETARY, UNITED STATES DEPARTMENT OF COMMERCE Washington, DC 20231 (US)	(72) Inventors: MOSS, Bernard Bethesda, MD 20814 (US) FALKNER, Falko, G. A-2304 Mannsdorf 116 (AT) (74) Representative: Lord, Hilton David, et al  MARKS & CLERK, 57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)