(19)

(11)

EP 0 406 294 A1

(12)

(43) Date of publication: 09.01.1991 Bulletin 1991/02 (21) Application number: 89904165.0 (22) Date of filing: 16.03.1989

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 15/ 53( . ) C12N 9/ 04( . ) C12R 1/ 07( . ) (86) International application number: PCT/GB1989/000279 (87) International publication number: WO 1989/008707 (21.09.1989 Gazette 1989/23)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 17.03.1988 GB 19880006358 (71) Applicants: UNIVERSITY OF BRISTOL Bristol BS8 1TH (GB) PUBLIC HEALTH LABORATORY SERVICE BOARD London NW9 5DF (GB)	(72) Inventors: HOLBROOK, J., John Bath BA3 1HN (GB) CLARKE, Anthony, R. Redland BS6 6NR (GB) ATKINSON, Anthony Salisbury (GB) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)