(19)
(11) EP 0 407 543 A1

(12)

(43) Date of publication:
16.01.1991 Bulletin 1991/03

(21) Application number: 90902001.0

(22) Date of filing: 22.12.1989
(51) International Patent Classification (IPC): 
G01N 33/ 53( . )
A61K 39/ 395( . )
A61P 25/ 00( . )
C07K 1/ 107( . )
C07K 5/ 10( . )
C07K 7/ 08( . )
C07K 14/ 435( . )
C07K 14/ 48( . )
C07K 16/ 00( . )
C07K 19/ 00( . )
C12N 15/ 09( . )
C12P 21/ 00( . )
C12R 1/ 91( . )
A61K 38/ 00( . )
A61K 47/ 48( . )
A61P 25/ 28( . )
C07K 1/ 22( . )
C07K 7/ 06( . )
C07K 14/ 00( . )
C07K 14/ 47( . )
C07K 14/ 52( . )
C07K 16/ 18( . )
C12N 5/ 10( . )
C12N 15/ 85( . )
C12P 21/ 08( . )
(86) International application number:
PCT/US1989/005808
(87) International publication number:
WO 1990/006948 (28.06.1990 Gazette 1990/15)
(84) Designated Contracting States:
AT BE CH DE ES FR GB IT LI LU NL SE

(30) Priority: 22.12.1988 US 19880288604
02.02.1989 US 19890305239
01.09.1989 US 19890401408

(71) Applicants:
  • FISHMAN, Mark C.
    Boston, MA 02116 (US)
  • FEDEROFF, Howard J.
    Boston, MA 02114 (US)
  • ZUBER, Mauricio X.
    Boston, MA 02114 (US)
  • STRITTMATTER, Stephen M.
    Boston, MA 02114 (US)
  • VALENZUELA, Dario
    Boston, MA 02114 (US)

(72) Inventors:
  • FISHMAN, Mark C.
    Boston, MA 02116 (US)
  • FEDEROFF, Howard J.
    Boston, MA 02114 (US)
  • ZUBER, Mauricio X.
    Boston, MA 02114 (US)
  • STRITTMATTER, Stephen M.
    Boston, MA 02114 (US)
  • VALENZUELA, Dario
    Boston, MA 02114 (US)

(74) Representative: Sheard, Andrew Gregory, et al 
Kilburn & Strode 30, John Street
London WC1N 2DD
London WC1N 2DD (GB)

   


(54) MAMMALIAN GAP-43 COMPOSITIONS AND METHODS OF USE