(19)

(11)

EP 0 409 923 A1

(12)

(43) Date of publication: 30.01.1991 Bulletin 1991/05 (21) Application number: 90900688.0 (22) Date of filing: 13.12.1989

(51) International Patent Classification (IPC):  C12P 21/ 08( . ) C07K 1/ 22( . ) C07K 14/ 435( . ) C07K 14/ 445( . ) A61K 39/ 00( . ) A61K 39/ 015( . ) C07K 14/ 00( . ) C07K 14/ 44( . ) C12N 15/ 85( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1989/005550 (87) International publication number: WO 1990/007006 (28.06.1990 Gazette 1990/15)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 21.12.1988 US 19880287934 (71) Applicant: SMITHKLINE BIOLOGICALS B-1320 Genval (BE)

(72) Inventors: BOLLEN, Alex B-1711 Itterbeek (BE) GILLES, Pascal B-1400 Nivelles (BE) HEINDERYCKX, Michel B-6332 Boignee (BE) JACOBS, Paul B-7806 Ath (BE) JOHANSEN, Hanne, Ranch Jeffersonville, PA 19403 (US) MASSAER, Marc B-1500 Halle (BE) ROSENBERG, Martin Royersford, PA 19468 (US) (74) Representative: West, Vivien, et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)