(19)

(11)

EP 0 410 974 A1

(12)

(43) Date of publication: 06.02.1991 Bulletin 1991/06 (21) Application number: 89903414.0 (22) Date of filing: 09.02.1989

(51) International Patent Classification (IPC):  A61K 49/ 04( . ) C07C 237/ 46( . ) C07C 237/ 42( . ) (86) International application number: PCT/US1989/000519 (87) International publication number: WO 1989/008101 (08.09.1989 Gazette 1989/21)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 01.03.1988 US 19880162632 (71) Applicant: MALLINCKRODT, INC. St. Louis, MI 63134 (US)	(72) Inventors: WHITE, David, H. St. Louis, MO 63134 (US) LIN, Youlin St. Louis, MO 63134 (US) (74) Representative: Allard, Susan Joyce, et al  BOULT, WADE & TENNANT 27 Furnival Street London EC4A 1PQ London EC4A 1PQ (GB)