(19)

(11)

EP 0 412 105 A1

(12)

(43) Date of publication: 13.02.1991 Bulletin 1991/07 (21) Application number: 89905435.0 (22) Date of filing: 21.04.1989

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61P 35/ 00( . ) C07K 14/ 435( . ) C07K 16/ 00( . ) C12P 21/ 00( . ) C12R 1/ 91( . ) A61K 38/ 00( . ) C07K 1/ 22( . ) C07K 14/ 52( . ) C12N 15/ 06( . ) C12P 21/ 08( . ) (86) International application number: PCT/GB1989/000396 (87) International publication number: WO 1989/010133 (02.11.1989 Gazette 1989/26)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 21.04.1988 GB 19880009419 (71) Applicant: CANCER RESEARCH CAMPAIGN TECHNOLOGY LTD. London SW1Y 5AR (GB)	(72) Inventor: PRAGNELL,Ian,Bernard Glasgow G61 1BD G (GB) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)