(19)

(11)

EP 0 413 003 A1

(12)

(43) Date of publication: 20.02.1991 Bulletin 1991/08 (21) Application number: 89909007.0 (22) Date of filing: 31.07.1989

(51) International Patent Classification (IPC):  C12Q 1/ 68( . ) (86) International application number: PCT/GB1989/000875 (87) International publication number: WO 1990/001561 (22.02.1990 Gazette 1990/05)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 29.07.1988 GB 19880018076 (71) Applicant: UNIVERSITY COLLEGE LONDON London WC1E 6HA (GB)	(72) Inventors: GURLING, Hugh University College and Riding House Street London W1N 8AA (GB) SHERRINGTON, Robin University College and Riding House Street London W1N 8AA (GB) (74) Representative: Marchant, James Ian, et al  Elkington and Fife Prospect House 8 Pembroke Road Sevenoaks, Kent TN13 1XR Sevenoaks, Kent TN13 1XR (GB)