(19)

(11)

EP 0 413 687 A1

(12)

(43) Date of publication: 27.02.1991 Bulletin 1991/09 (21) Application number: 88906718.0 (22) Date of filing: 13.05.1988

(51) International Patent Classification (IPC):  A61K 39/ 29( . ) C07K 14/ 75( . ) C12N 9/ 64( . ) A61L 2/ 00( . ) C07K 14/ 755( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1988/001587 (87) International publication number: WO 1988/008710 (17.11.1988 Gazette 1988/25)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 15.05.1987 US 19870050153 12.05.1988 US 19880193449 (71) Applicant: Rubinstein, Alan I. Beverley Hills California 90210 (US)	(72) Inventor: Rubinstein, Alan I. Beverley Hills California 90210 (US) (74) Representative: Holdcroft, James Gerald, Dr., et al  Graham Watt & Co., Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)