(19)

(11)

EP 0 413 758 A1

(12)

(43) Date of publication: 27.02.1991 Bulletin 1991/09 (21) Application number: 89906274.0 (22) Date of filing: 02.05.1989

(51) International Patent Classification (IPC):  G01N 33/ 538( . ) G01N 33/ 553( . ) G01N 33/ 94( . ) G01N 33/ 543( . ) G01N 33/ 58( . ) G01N 35/ 00( . ) (86) International application number: PCT/US1989/001862 (87) International publication number: WO 1989/011102 (16.11.1989 Gazette 1989/27)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 04.05.1988 US 19880189983 (71) Applicant: ANGENICS INC. Cambridge, MA 02139 (US)	(72) Inventors: COX, Daniel, E. Franklin, MA 02038 (US) ABRIL, Obsidiana Cambridge, MA 02138 (US) BAUMINGER, Sara Newton, MA 02159 (US) NERI, Bruce, P. North Andover, MA 01845 (US) SHINEFELD, Lisa Lexington, MA 02173 (US) (74) Representative: Holdcroft, James Gerald, Dr.  Graham Watt & Co., Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)