(19)
(11) EP 0 415 929 A1

(12)

(43) Date of publication:
13.03.1991 Bulletin 1991/11

(21) Application number: 89901891.0

(22) Date of filing: 12.01.1989
(51) International Patent Classification (IPC): 
C12N 15/ 02( . )
C07K 16/ 46( . )
C12P 21/ 08( . )
C12R 1/ 91( . )
A61K 39/ 395( . )
C12N 5/ 10( . )
A61K 38/ 00( . )
(86) International application number:
PCT/US1989/000123
(87) International publication number:
WO 1989/006544 (27.07.1989 Gazette 1989/16)
(84) Designated Contracting States:
AT BE CH DE FR GB IT LI LU NL SE

(30) Priority: 15.01.1988 US 19880144541

(71) Applicant: CENTOCOR, INC.
Malvern, PA 19355 (US)

(72) Inventors:
  • KLUG, Thomas, L.
    West Chester, PA 19380 (US)
  • BAINE, Yaela
    Merion, PA 19066 (US)
  • MILLER, Richard, W.
    Phoenixville, PA 19460 (US)
  • LeDONNE, Norman
    Downingtown, PA 19335 (US)

(74) Representative: Holdcroft, James Gerald, Dr., et al 
Graham Watt & Co., Riverhead
Sevenoaks, Kent TN13 2BN
Sevenoaks, Kent TN13 2BN (GB)

   


(54) HETEROLIGATING ANTIBODIES AND THERAPEUTIC USES THEREOF