(19)

(11)

EP 0 416 011 A1

(12)

(43) Date of publication: 13.03.1991 Bulletin 1991/11 (21) Application number: 89906537.0 (22) Date of filing: 12.05.1989

(51) International Patent Classification (IPC):  A61K( . ) A61K 9/ 127( . ) A61K 31/ 24( . ) A61K 31/ 44( . ) A61K 31/ 47( . ) A61K 31/ 495( . ) A61K 31/ 52( . ) A61K 31/ 70( . ) A61P 31/ 12( . ) A61P 37/ 04( . ) A61K 45/ 06( . ) A61K 9/ 66( . ) A61K 31/ 40( . ) A61K 31/ 445( . ) A61K 31/ 475( . ) A61K 31/ 505( . ) A61K 31/ 55( . ) A61K 45/ 00( . ) A61P 31/ 18( . ) B01J 13/ 02( . ) (86) International application number: PCT/US1989/002034 (87) International publication number: WO 1989/011274 (30.11.1989 Gazette 1989/28)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 16.05.1988 US 19880194171 05.04.1989 US 19890334089 (71) Applicant: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, U.S. DEPARTMENT OF COMMERCE Springfield, VA 22161 (US)	(72) Inventors: WEINSTEIN, John, N. Chevy Chase, MD 20815 (US) SZEBENI, Janos Bethesda, MD 20817 (US) (74) Representative: Jump, Timothy John Simon, et al  Venner Shipley & Co. 20 Little Britain London EC1A 7DH London EC1A 7DH (GB)