(19)

(11)

EP 0 416 032 A1

(12)

(43) Date of publication: 13.03.1991 Bulletin 1991/11 (21) Application number: 89907434.0 (22) Date of filing: 18.05.1989

(51) International Patent Classification (IPC):  A01H 1/ 00( . ) C12N 9/ 10( . ) C12N 15/ 09( . ) C12N 15/ 82( . ) C07K 14/ 415( . ) C12N 9/ 88( . ) C12N 15/ 10( . ) C12Q 1/ 68( . ) (86) International application number: PCT/US1989/002151 (87) International publication number: WO 1989/012230 (14.12.1989 Gazette 1989/29)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 20.05.1988 US 19880197122 26.04.1989 US 19890343446 (71) Applicant: THE SALK INSTITUTE BIOTECHNOLOGY INDUSTRIAL ASSOCIATES, INC. La Jolla, CA 92037 (US)	(72) Inventors: FITZMAURICE, Leona, Claire San Diego, CA 92131 (US) LAMB, Christopher, John San Diego, CA 92122 (US) (74) Representative: Allard, Susan Joyce  BOULT, WADE & TENNANT 27 Furnival Street London EC4A 1PQ London EC4A 1PQ (GB)