(19)

(11)

EP 0 417 245 A1

(12)

(43) Date of publication: 20.03.1991 Bulletin 1991/12 (21) Application number: 90905333.0 (22) Date of filing: 15.03.1990

(51) International Patent Classification (IPC):  A61K 31/ 13( . ) A61K 31/ 60( . ) A61K 47/ 14( . ) A61P 25/ 04( . ) A61K 9/ 08( . ) A61K 47/ 10( . ) A61K 47/ 18( . ) (86) International application number: PCT/US1990/001419 (87) International publication number: WO 1990/011014 (04.10.1990 Gazette 1990/23)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 17.03.1989 US 19890324912 (71) Applicant: NASTECH PHARMACEUTICAL COMPANY, INC. Hauppauge, NY 11788 (US)	(72) Inventors: WENIG, Jeffrey Dix Hills, NY 11746 (US) ROMEO, Vincent North Massapequa, NY 11758 (US) (74) Representative: Weinhold, Peter, Dr.  Patentanwälte Dr. Weinhold, Dannenberg, Dr. Gudel, Schubert Siegfriedstrasse 8 D-80803 München D-80803 München (DE)