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EP 0 418 292 A1

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(43) Date of publication: 27.03.1991 Bulletin 1991/13 (21) Application number: 89906634.0 (22) Date of filing: 25.05.1989

(51) International Patent Classification (IPC):  A61K 31/ 685( . ) C07F 9/ 24( . ) C07F 9/ 58( . ) C07F 9/ 6533( . ) A61P 35/ 00( . ) C07F 9/ 572( . ) C07F 9/ 6506( . ) (86) International application number: PCT/US1989/002299 (87) International publication number: WO 1989/011484 (30.11.1989 Gazette 1989/28)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 25.05.1988 US 19880198408 (71) Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC. Tucson Arizona 85710-2815 (US)	(72) Inventors: BORCH, Richard, F. Pittsford, NY 14534 (US) CANUTE, Gregory, W. Ann Arbor, MI 48105 (US) VALENTE, Ronald, R. Rochester, NY 14620 (US) (74) Representative: Hansen, Bernd, Dr. Dipl.-Chem., et al  Hoffmann, Eitle & Partner Patent- und Rechtsanwälte, Postfach 81 04 20 D-81904 München D-81904 München (DE)