(19)

(11)

EP 0 419 462 A1

(12)

(43) Date of publication: 03.04.1991 Bulletin 1991/14 (21) Application number: 88906547.0 (22) Date of filing: 12.07.1988

(51) International Patent Classification (IPC):  A61K 47/ 48( . ) A61K 51/ 10( . ) (86) International application number: PCT/US1988/002343 (87) International publication number: WO 1989/000583 (26.01.1989 Gazette 1989/03)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 17.07.1987 US 19870074824 (71) Applicant: Xoma Corporation Berkeley California 94710 (US)	(72) Inventors: SCANNON, Patrick, J. Davis, CA 95616 (US) KAWAHATA, Russell, T. San Anselmo, CA 94960 (US) (74) Representative: Glawe, Delfs, Moll & Partner  Patentanwälte Postfach 26 01 62 D-80058 München D-80058 München (DE)