(19)

(11)

EP 0 422 021 A1

(12)

(43) Date of publication: 17.04.1991 Bulletin 1991/16 (21) Application number: 89906114.0 (22) Date of filing: 31.05.1989

(51) International Patent Classification (IPC):  A61K 49/ 00( . ) A61K 49/ 18( . ) A61B 5/ 055( . ) (86) International application number: PCT/EP1989/000613 (87) International publication number: WO 1989/011873 (14.12.1989 Gazette 1989/29)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 03.06.1988 GB 19880013144 (71) Applicant: NYCOMED AS N-0401 Oslo 4 (NO)	(72) Inventors: KLAVENESS, Jo N-0276 Oslo 2 (NO) THOMASSEN, Terje N-1273 Oslo 12 (NO) (74) Representative: Cockbain, Julian, Dr., et al  Frank B. Dehn & Co. Imperial House 15-19 Kingsway London WC2B 6UZ London WC2B 6UZ (GB)