(19)

(11)

EP 0 422 055 A1

(12)

(43) Date of publication: 17.04.1991 Bulletin 1991/16 (21) Application number: 89907146.0 (22) Date of filing: 21.06.1989

(51) International Patent Classification (IPC):  A61K 31/ 575( . ) A61P 1/ 16( . ) A61P 1/ 00( . ) C07J 51/ 00( . ) (86) International application number: PCT/EP1989/000699 (87) International publication number: WO 1990/000175 (11.01.1990 Gazette 1990/02)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 28.06.1988 IT 19880021135 (71) Applicant: ISTITUTO CHEMIOTERAPICO DI LODI S.P.A. I-20075 S. Grato, Lodi (IT)	(72) Inventors: SCOLASTICO, Carlo I-20100 Milano (IT) PALAZZI, Camillo Maria Francesco Giulio I-20073 Codogno (IT) (74) Representative: Minoja, Fabrizio  Studio Consulenza Brevettuale, Via Rossini, 8 I-20122 Milano I-20122 Milano (IT)