(19)

(11)

EP 0 423 206 A1

(12)

(43) Date of publication: 24.04.1991 Bulletin 1991/17 (21) Application number: 89908237.0 (22) Date of filing: 07.07.1989

(51) International Patent Classification (IPC):  G01N 21/ 76( . ) C12Q 1/ 28( . ) C12Q 1/ 34( . ) C12Q 1/ 44( . ) G01N 33/ 50( . ) C12Q 1/ 02( . ) C12Q 1/ 32( . ) C12Q 1/ 42( . ) G01N 21/ 78( . ) G01N 33/ 74( . ) (86) International application number: PCT/GB1989/000775 (87) International publication number: WO 1990/000619 (25.01.1990 Gazette 1990/03)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 08.07.1988 GB 19880018508 04.08.1988 GB 19880016302 (71) Applicant: UNIVERSITY COLLEGE LONDON London WC1E 6HA (GB)	(72) Inventors: MARSHALL, N.J. c/o Dept. of Chemical Pathology London W1P 6DB (GB) EALEY, Patricia A. c/o Dept. of Chemical Pathology London W1P 6DB (GB) HOLT, Stanley J.,University College London London WC1E 6BT (GB) (74) Representative: Collier, Jeremy Austin Grey  J.A.KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)