(19)

(11)

EP 0 424 386 A1

(12)

(43) Date of publication: 02.05.1991 Bulletin 1991/18 (21) Application number: 89903426.0 (22) Date of filing: 24.02.1989

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61K 38/ 18( . ) A61K 38/ 43( . ) A61K 47/ 42( . ) A61L 27/ 16( . ) A61L 27/ 22( . ) A61L 27/ 54( . ) A61P 9/ 14( . ) C07K 14/ 745( . ) C12N 5/ 071( . ) A61K 31/ 00( . ) A61K 38/ 22( . ) A61K 38/ 46( . ) A61K 48/ 00( . ) A61L 27/ 18( . ) A61L 27/ 50( . ) A61L 27/ 58( . ) C07K 14/ 52( . ) C07K 17/ 02( . ) (86) International application number: PCT/US1989/000742 (87) International publication number: WO 1989/007944 (08.09.1989 Gazette 1989/21)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 24.02.1988 US 19880159730 26.01.1989 US 19890301591 (71) Applicants: AMERICAN NATIONAL RED CROSS Washington, DC 20006 (US) THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Springfield, Virginia 22161 (US)	(72) Inventors: THOMPSON, John, A. Myersville, MD 21773 (US) ANDERSON, W., French Bethesda, MD 20817 (US) MACIAG, Thomas Rockville, MD 20852 (US) (74) Representative: Atkinson, Peter Birch, et al  Marks & Clerk Suite 301 Sunlight House Quay Street Manchester M3 3JY Manchester M3 3JY (GB)