(19)

(11)

EP 0 424 470 A1

(12)

(43) Date of publication: 02.05.1991 Bulletin 1991/18 (21) Application number: 89909328.0 (22) Date of filing: 21.06.1989

(51) International Patent Classification (IPC):  A61K 38/ 55( . ) A61P 1/ 00( . ) A61K 38/ 57( . ) (86) International application number: PCT/US1989/002666 (87) International publication number: WO 1990/000615 (25.01.1990 Gazette 1990/03)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 14.07.1988 US 19880218922 (71) Applicant: AMGEN BOULDER INC. Boulder, CO 80301-2546 (US)	(72) Inventors: OHLSSON, Kjell S-27021 Glenmingebro (SE) THOMPSON, Robert, C. Boulder, CO 80303 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Maximilianstrasse 58 D-80538 München D-80538 München (DE)