(19)

(11)

EP 0 424 524 A1

(12)

(43) Date of publication: 02.05.1991 Bulletin 1991/18 (21) Application number: 90908990.0 (22) Date of filing: 10.05.1990

(51) International Patent Classification (IPC):  A61J 7/ 04( . ) B65D 83/ 04( . ) (86) International application number: PCT/US1990/002629 (87) International publication number: WO 1990/013878 (15.11.1990 Gazette 1990/26)

(84) Designated Contracting States: AT BE CH DE ES FR GB IT LI LU NL SE (30) Priority: 11.05.1989 US 19890350369 (71) Applicant: ORTHO PHARMACEUTICAL CORPORATION Raritan New Jersey 08869-0602 (US)	(72) Inventors: HIRST, Richard, Norman Teaneck, NJ 07666 (US) EDSTROM, Richard, C. New York, NY 10022 (US) GERSTMAN, Richard Tenafly, NJ 07670 (US) (74) Representative: Mercer, Christopher Paul, et al  Carpmaels & Ransford 43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)