(19)

(11)

EP 0 427 771 A1

(12)

(43) Date of publication: 22.05.1991 Bulletin 1991/21 (21) Application number: 89909106.0 (22) Date of filing: 28.07.1989

(51) International Patent Classification (IPC):  A61K 31/ 70( . ) A61K 31/ 7052( . ) C07H 17/ 02( . ) C12P 19/ 60( . ) A61K 31/ 7042( . ) A61P 31/ 04( . ) C12N 1/ 20( . ) C12R 1/ 03( . ) (86) International application number: PCT/US1989/003209 (87) International publication number: WO 1990/001491 (22.02.1990 Gazette 1990/05)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 03.08.1988 US 19880227951 03.08.1988 US 19880227963 03.08.1988 US 19880227964 03.08.1988 US 19880227968 (71) Applicant: SCHERING CORPORATION Kenilworth New Jersey 07033 (US)

(72) Inventors: HEGDE, Vinod, R. Rockaway, NJ 07866 (US) HORAN, Ann, C. Summit, NJ 07901 (US) KING, Arthur, H. East Orange, NJ 07017 (US) GENTILE, Frank, A. Wayne, NJ 07470 (US) PATEL, Mahesh, G. Verona, NJ 07044 (US) WAGMAN, Gerald, H. East Brunswick, NJ 08816 (US) GUNNARSSON, Ingrid-Agneta Hackettstown, NJ 07840 (US) COOPER, Raymond East Brunswick, NJ 08816 (US) TRUUMEES, Imbi Cresskill, NJ 07626 (US) YARBOROUGH, Raymond, F. Orange, NJ 07050 (US) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)