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(11)

EP 0 428 603 A1

(12)

(43) Date of publication: 29.05.1991 Bulletin 1991/22 (21) Application number: 89909503.0 (22) Date of filing: 24.07.1989

(51) International Patent Classification (IPC):  C07K 14/ 21( . ) C07K 16/ 00( . ) C07K 14/ 73( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1989/003267 (87) International publication number: WO 1990/001035 (08.02.1990 Gazette 1990/04)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 22.07.1988 US 19880223270 13.12.1988 US 19880283739 27.04.1989 US 19890344304 (71) Applicant: THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE Washington, DC 20002 (US)

(72) Inventors: BERGER, Edward, A. Rockville, MD 20852 (US) MOSS, Bernard Bethesda, MD 20814 (US) FUERST, Thomas, R. Gaithersburg, MD 20877 (US) MIZUKAMI, Tamio Bethesda, MD 20814 (US) PASTAN, Ira, H. Potomac, MD 20854 (US) FITZGERALD, David, J., P. Silver Spring, MD 20902 (US) CHAUDHARY, Vijay, K. Rockville, MD 20851 (US) (74) Representative: Jump, Timothy John Simon, et al  Venner Shipley & Co. 20 Little Britain London EC1A 7DH London EC1A 7DH (GB)