PRODUCTION OF RADIOIODINATED 1-$g(b)-D-ARABINOFURANOSYL)-5(E)-(2-IODOVINYL)URACIL, AND USES THEREOF, AND RELATED ANALOGUES INCORPORATING ALTERNATIVE HALOGEN RADIONUCLIDES, THE GENERAL RADIOHALOGENATION PRECURSORS, 1-(2,3,5-TRI-O-ACETYL-$g(b)-D-ARABINOFURANOSYL)-5(Z and E)-(2-TRIMETHYLSILYLVINYL)URAC

(19)

(11)

EP 0 428 623 A1

(12)

(43)	Date of publication:
	29.05.1991 Bulletin 1991/22

(21)	Application number: 89910499.0

(22)	Date of filing: 08.08.1989

(51)

International Patent Classification (IPC):

A61K 51/ 04^{( . )}

(86)	International application number:
	PCT/US1989/003396

(87)	International publication number:
	WO 1990/001324 (22.02.1990 Gazette 1990/05)

(84)	Designated Contracting States:
	AT BE CH DE FR GB IT LI LU NL SE

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Priority:

10.08.1988 US 19880231137

(71)	Applicants:
	SACKS, Stephen Leslie Vancouver, British Columbia V6S 1L1 (CA) ROBINS, Morris J. Provo, UT 84604 (US)

(72)	Inventors:
	SACKS, Stephen Leslie Vancouver, British Columbia V6S 1L1 (CA) ROBINS, Morris J. Provo, UT 84604 (US)

(74)	Representative: Kraus, Walter, Dr., et al
	Patentanwälte Kraus, Weisert & Partner Thomas-Wimmer-Ring 15 D-80539 München D-80539 München (DE)

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PRODUCTION OF RADIOIODINATED 1-$g(b)-D-ARABINOFURANOSYL)-5(E)-(2-IODOVINYL)URACIL, AND USES THEREOF, AND RELATED ANALOGUES INCORPORATING ALTERNATIVE HALOGEN RADIONUCLIDES, THE GENERAL RADIOHALOGENATION PRECURSORS, 1-(2,3,5-TRI-O-ACETYL-$g(b)-D-ARABINOFURANOSYL)-5(Z and E)-(2-TRIMETHYLSILYLVINYL)URAC