(19)

(11)

EP 0 431 045 A1

(12)

(43) Date of publication: 12.06.1991 Bulletin 1991/24 (21) Application number: 89909945.0 (22) Date of filing: 21.08.1989

(51) International Patent Classification (IPC):  A01K 67/ 027( . ) C07K 14/ 73( . ) C12N 5/ 10( . ) A61K 38/ 00( . ) A61K 39/ 21( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) C12R 1/ 19( . ) (86) International application number: PCT/US1989/003541 (87) International publication number: WO 1990/001870 (08.03.1990 Gazette 1990/06)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 22.08.1988 US 19880234646 18.08.1989 US 19890395454 (71) Applicant: THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Springfield, Virginia 22161 (US)	(72) Inventors: ANDERSON, W., French Bethesda, MD 20817 (US) GALLO, Robert, C. Bethesda, MD 20814 (US) WONG-STAAL, Flossie Potomac, MD 20854 (US) MORGAN, Richard, A. Elkridge, MD 21227 (US) MUENCHAU, Daryl Columbia, MD 21046 (US) (74) Representative: Lamb, John Baxter, et al  MARKS & CLERK, 57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)