(19)

(11)

EP 0 431 113 A1

(12)

(43) Date of publication: 12.06.1991 Bulletin 1991/24 (21) Application number: 90909101.0 (22) Date of filing: 23.05.1990

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 7/ 10( . ) C07K 7/ 08( . ) C07K 14/ 58( . ) A61K 38/ 22( . ) A61P 9/ 12( . ) C07K 14/ 575( . ) (86) International application number: PCT/US1990/002917 (87) International publication number: WO 1990/014362 (29.11.1990 Gazette 1990/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 24.05.1989 US 19890356980 (71) Applicant: ABBOTT LABORATORIES Abbott Park, Illinois 60064-3500 (US)	(72) Inventors: LUCAS, Scott, D. Tempe, AZ 85284 (US) ROCKWAY, Todd, W. Mundelein, IL 60060 (US) DAVIDSEN, Steven, K. Mundelein, IL 60060 (US) THOMAS, A., Mitchell Wadsworth, IL 60083 (US) VON GELDERN, Thomas, W. Richmond, IL 60071 (US) (74) Representative: Modiano, Guido, Dr.-Ing., et al  Modiano & Associati S.r.l. Via Meravigli, 16 I-20123 Milano I-20123 Milano (IT)