(19)

(11)

EP 0 433 425 A1

(12)

(43) Date of publication: 26.06.1991 Bulletin 1991/26 (21) Application number: 90910622.0 (22) Date of filing: 03.07.1990

(51) International Patent Classification (IPC):  C07D( . ) A61K 31/ 431( . ) C07D 317/ 40( . ) C07D 499/ 88( . ) C07D 499/ 897( . ) A61K 31/ 43( . ) A61P 31/ 04( . ) C07D 499/ 06( . ) C07D 499/ 883( . ) (86) International application number: PCT/EP1990/001060 (87) International publication number: WO 1991/000283 (10.01.1991 Gazette 1991/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI NL SE (30) Priority: 05.07.1989 GB 19890015392 (71) Applicant: FARMITALIA CARLO ERBA S.r.l. I-20159 Milano (IT)	(72) Inventors: PERRONE, Ettore I-20010 Boffalora Ticino (IT) ALPEGIANI, Marco I-20132 Milan (IT) ZARINI, Franco I-20019 Settimo Milanese (IT) MAZZINI, Giuseppe I-20144 Milan (IT) FRANCESCHI, Giovanni I-20153 Milan (IT) (74) Representative: Myerscough, Philip Boyd, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)