(19)

(11)

EP 0 434 731 A1

(12)

(43) Date of publication: 03.07.1991 Bulletin 1991/27 (21) Application number: 89910484.0 (22) Date of filing: 12.09.1989

(51) International Patent Classification (IPC):  C07D 263/ 10( . ) C07D 263/ 14( . ) C07D 263/ 12( . ) (86) International application number: PCT/US1989/003827 (87) International publication number: WO 1990/002738 (22.03.1990 Gazette 1990/07)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 14.09.1988 US 19880244126 (71) Applicant: SCHERING CORPORATION Kenilworth, NJ 07030 (US)	(72) Inventors: SCHUMACHER, Doris, P. Florham Park, NJ 07932 (US) CLARK, Jon, E. Highland Park, NJ 08904 (US) MURPHY, Bruce, L. Glen Ridge, NJ 07028 (US) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)