(19)

(11)

EP 0 435 948 A1

(12)

(43) Date of publication: 10.07.1991 Bulletin 1991/28 (21) Application number: 89911347.0 (22) Date of filing: 21.09.1989

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 25/ 18( . ) A61K 38/ 04( . ) C07K 14/ 575( . ) (86) International application number: PCT/US1989/004118 (87) International publication number: WO 1990/003392 (05.04.1990 Gazette 1990/08)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 23.09.1988 US 19880248917 (71) Applicant: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES La Jolla California 92037 (US)	(72) Inventors: RIVIER, Jean, Edouard, Frederic La Jolla, CA 92037 (US) VALE, Wylie, Walker, Jr. La Jolla, CA 92037 (US) (74) Representative: Allard, Susan Joyce, et al  BOULT, WADE & TENNANT 27 Furnival Street London EC4A 1PQ London EC4A 1PQ (GB)