(19)

(11)

EP 0 437 564 A1

(12)

(43) Date of publication: 24.07.1991 Bulletin 1991/30 (21) Application number: 90910786.0 (22) Date of filing: 16.07.1990

(51) International Patent Classification (IPC):  C12N 1/ 04( . ) C12N 1/ 20( . ) (86) International application number: PCT/GB1990/001093 (87) International publication number: WO 1991/001366 (07.02.1991 Gazette 1991/04)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 14.07.1989 GB 19890016152 (71) Applicant: BIOSPHERE CORPORATION S.A. CH-1180 Rolle (CH)	(72) Inventor: HORSFALL, Frank, L., III Shaker Heights, OH 44120 (US) (74) Representative: Smith, Martin Stanley  Stevens, Hewlett & Perkins 1 St. Augustine's Place Bristol BS1 4UD Bristol BS1 4UD (GB)