(19)

(11)

EP 0 438 445 A1

(12)

(43) Date of publication: 31.07.1991 Bulletin 1991/31 (21) Application number: 89911156.0 (22) Date of filing: 14.09.1989

(51) International Patent Classification (IPC):  C12N 1/ 38( . ) C12R 1/ 465( . ) C12P 17/ 18( . ) (86) International application number: PCT/US1989/003910 (87) International publication number: WO 1990/004034 (19.04.1990 Gazette 1990/09)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 11.10.1988 US 19880255819 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, Michigan 49001 (US)	(72) Inventors: BANNISTER, Brian Kalamazoo, MI 49008 (US) CIALDELLA, Joyce, I. Kalamazoo, MI 49008 (US) DOLAK, Lester, A. Plainwell, MI 49080 (US) MARSHALL, Vincent, P. Kalamazoo, MI 49001 (US) MCWETHY, Steven, J. Kalamazoo, MI 49008 (US) (74) Representative: Perry, Robert Edward, et al  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)